9H-Fluoren-9-ylmethyl (2-oxoethyl)carbamate

9H-Fluoren-9-ylmethyl (2-oxoethyl)carbamate - Names and Identifiers

Name	(9H-Fluoren-9-yl)methyl 2-oxoethylcarbamate
Synonyms	Fmoc-Gly-al N-9-Fluorenylmethoxycarbonylglycinaldehyde (9H-Fluoren-9-yl)methyl 2-oxoethylcarbamate 9H-Fluoren-9-ylmethyl (2-oxoethyl)carbamate 9H-fluoren-9-ylmethyl N-(2-oxoethyl)carbamate 2-[[(9-Fluorenylmethoxy)carbonyl]amino]acetaldehyde carbamic acid, N-(2-oxoethyl)-, 9H-fluoren-9-ylmethyl ester Carbamic acid, N-(2-oxoethyl)-, 9H-fluoren-9-ylmethyl ester
CAS	156939-62-7
InChI	InChI=1/C17H15NO3/c19-10-9-18-17(20)21-11-16-14-7-3-1-5-12(14)13-6-2-4-8-15(13)16/h1-8,10,16H,9,11H2,(H,18,20)

9H-Fluoren-9-ylmethyl (2-oxoethyl)carbamate - Physico-chemical Properties

Molecular Formula	C17H15NO3
Molar Mass	281.31
Density	1.230±0.06 g/cm3(Predicted)
Melting Point	141.0-143.0℃
Boling Point	477.5±28.0 °C(Predicted)
Flash Point	242.558°C
Vapor Presure	0mmHg at 25°C
pKa	10.72±0.46(Predicted)
Storage Condition	Inert atmosphere,Store in freezer, under -20°C
Refractive Index	1.598

9H-Fluoren-9-ylmethyl (2-oxoethyl)carbamate - Introduction

(9H-Fluoren-9-yl)methyl 2-oxoethylcarbamate(N-Fmoc glycylaldehyde) is an organic compound commonly used in peptide synthesis in solid-phase synthesis.

Nature:
N-Fmoc glycylaldehyde is a white solid with good solubility and is soluble in some organic solvents such as dimethyl sulfoxide (DMSO) and chloroform. It is relatively stable at room temperature, but stored in the dark can extend its life.

Use:
N-Fmoc glycylaldehyde is mainly used for protecting groups in the process of peptide synthesis in solid phase synthesis. In the early stages of peptide synthesis, it can be added to the amino group of the peptide chain to protect its reactivity. After the synthesis is complete, the N-Fmoc group can be removed by treatment with a strong acid such as hydrofluoric acid to obtain a pure peptide product.

Method:
N-Fmoc glycyraldehyde can be obtained by reacting the Fmoc group with glycyraldehyde. The specific synthetic method may vary, but a typical method involves reacting glycylaldehyde with Fmoc-OSu(Fmoc hydroxysuccinimidyl carbonate) followed by alkaline treatment to obtain the desired product.

Safety Information:
N-Fmoc glycylaldehyde is an organic compound and needs to be operated in the laboratory. Appropriate protective equipment such as gloves and goggles should be worn during use. Direct contact should be avoided because the compound may cause irritation to the skin, eyes, and respiratory tract. In addition, it should be operated in a well-ventilated place, and pay attention to fire and explosion prevention measures. Specific safety operations and handling should be carried out in accordance with the laboratory's safety regulations.

Last Update：2024-04-09 21:04:16